| DOI | Resolve DOI: https://doi.org/10.1016/bs.afnr.2019.04.001 |
|---|
| Author | Search for: Ganguly, Advaita; Search for: Sharma, Kumakshi1; Search for: Majumder, Kaustav |
|---|
| Affiliation | - National Research Council of Canada. Health, Safety and Environment Branch
|
|---|
| Format | Text, Book Chapter |
|---|
| Subject | bioactive peptides; ACE inhibition; angiotensin-II; hypertension; anti-oxidant; anti-inflammation; cardiovascular diseases; renin-angiotensin system; oxidative stress; chronic inflammation; structural information; peptide therapeutics |
|---|
| Abstract | Non-communicable diseases including cardiovascular diseases (CVDs) and associated metabolic disorders are responsible for nearly 40 million deaths globally per year. Hypertension or high blood pressure (BP) is one of the primary reasons for the development of CVDs. A healthy nutritional strategy complementing with physical activity can substantially reduce high BP and prevent the occurrence of CVD-associated morbidity and mortality. Bioactive peptides currently are the next wave of the promising bench to clinic options for potential targeting chronic and acute health issues including hypertension. Peptides demonstrating anti-inflammatory, anti-oxidant, and angiotensin-converting enzyme-I inhibitory activity are widely studied for the amelioration of hypertension and associated CVDs. Isolating these potent bioactive peptides from different food sources is a promising endeavor toward nutraceutical based dietary management and prevention of hypertension. Understanding the pathophysiology of hypertension and the action mechanisms of the bioactive peptides would complement in designing and characterizing more potent peptides and suitable comprehensive dietary plans for the prevention of hypertension and associated CVDs. |
|---|
| Publication date | 2019-05-16 |
|---|
| Publisher | Elsevier |
|---|
| In | |
|---|
| Series | |
|---|
| Language | English |
|---|
| Peer reviewed | Yes |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | f9617628-c6a8-449e-8f41-59c4f8dacf85 |
|---|
| Record created | 2021-03-10 |
|---|
| Record modified | 2021-03-10 |
|---|
