| Download | - View author's version: Interlaboratory comparison on the quantification of total and accessible amine groups on silica nanoparticles with qNMR and optical assays (PDF, 594 KiB)
- View supplementary information: Interlaboratory comparison on the quantification of total and accessible amine groups on silica nanoparticles with qNMR and optical assays (PDF, 688 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1021/acs.analchem.1c02162 |
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| Author | Search for: Kunc, Filip1; Search for: Nirmalananthan-Budau, Nithiya; Search for: Rühle, Bastian; Search for: Sun, Ying1; Search for: Johnston, Linda J.1ORCID identifier: https://orcid.org/0000-0002-9136-4920; Search for: Resch-Genger, UteORCID identifier: https://orcid.org/0000-0002-0944-1115 |
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| Affiliation | - National Research Council of Canada. Metrology Research Centre
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| Format | Text, Article |
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| Subject | nanomaterials; amines; nanoparticles; silica; assays |
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| Abstract | Risk assessment of nanomaterials requires not only standardized toxicity studies but also validated methods for nanomaterial surface characterization with known uncertainties. In this context, a first bilateral interlaboratory comparison on surface group quantification of nanomaterials is presented that assesses different reporter-free and labeling methods for the quantification of the total and accessible number of amine functionalities on commercially available silica nanoparticles that are widely used in the life sciences. The overall goal of this comparison is the identification of optimum methods as well as achievable measurement uncertainties and the comparability of the results across laboratories. We also examined the robustness and ease of implementation of the applied analytical methods and discussed method-inherent limitations. In summary, this comparison presents a first step toward the eventually required standardization of methods for surface group quantification. |
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| Publication date | 2021-10-29 |
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| Publisher | American Chemical Society |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | f9830435-391e-4ca9-bfe2-5ffc1910998c |
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| Record created | 2021-12-03 |
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| Record modified | 2021-12-03 |
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