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Purification of capsular polysaccharide

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1385/1-59259-148-5:41
AuthorSearch for: 1; Search for: 1
Affiliation
  1. National Research Council of Canada. NRC Institute for Biological Sciences
FormatText, Book Chapter
Abstract
Meningococcus is an aerobic, fastidious, Gram-negative diplococcus that is found only in humans. Its cell wall has a cytoplasmic membrane, a peptidoglycan layer, and an outer membrane. Meningococci isolated from the bloodstream or the spinal fluid are almost always encapsulated. The capsules are polysaccharides, which consist of repeating sugar units (1,2). The capsular polysaccharide can be isolated, purified, and chemically and physically defined. Based on the chemical and immunological specificity of its capsular polysaccharides, Neisseria meningitidis has been classified serologically into groups A, B, C, 29E, H, I, K, L, W135, X, Y and Z (2). Of these, groups A, B, and C are responsible for approx 90% of meningococcal meningitis, and group B meningococcus is responsible for the majority of meningococcal disease in industrialized countries (1,2). The structures of the repeating units of the meningococcal polysaccharides have been elucidated and are shown in Table 1.
Publication date
PublisherHumana Press
Springer
In
  • Meningococcal Vaccines (2001): 41–47.
Series
  • Methods in Molecular Medicine 66.
LanguageEnglish
Peer reviewedYes
NRC numberYANG2001
NPARC number9366726
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Record identifierfa344fb4-620b-4acc-bf38-46c47218b90e
Record created2009-07-10
Record modified2022-07-07
Date modified: