| DOI | Resolve DOI: https://doi.org/10.1016/j.toxicon.2003.10.016 |
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| Author | Search for: Llewellyn, Lyndon; Search for: Negri, Andrew; Search for: Quilliam, Michael1 |
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| Affiliation | - National Research Council of Canada. Measurement Science and Standards
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| Format | Text, Article |
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| Subject | saxitoxin; sodium channel; paralytic shellfish poison; gymnodinium catenatum; hydroxybenzoate |
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| Abstract | The paralytic shellfish poison family has been recently extended by the discovery of several analogues possessing a hydoxybenzoate moiety instead of the carbamoyl group one finds in saxitoxin, the parent molecule of this toxin family. We have investigated the potency of these new analogues on a representative isoform of the pharmacological target of these toxins, the voltage gated sodium channel. These toxins were found to have KI's in the low nanomolar range, only slightly less potent than saxitoxin. The hydroxybenzoate group may increase the lipophilicity of these toxins and improve their ability to pass through epithelia and therefore its uptake and elimination in both intoxication victims and animals that bioaccumulate paralytic shellfish toxins. |
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| Publication date | 2004-01 |
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| Terms of use | - Copyright 2003 Elsevier Ltd. All rights reserved.
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | 1372 |
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| NPARC number | 3538514 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | fa42dff1-5176-402b-a1bf-ff9c12628fea |
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| Record created | 2009-03-01 |
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| Record modified | 2020-04-17 |
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