| DOI | Trouver le DOI : https://doi.org/10.1016/j.toxicon.2003.10.016 |
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| Auteur | Rechercher : Llewellyn, Lyndon; Rechercher : Negri, Andrew; Rechercher : Quilliam, Michael1 |
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| Affiliation | - Conseil national de recherches du Canada. Science des mesures et étalons
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| Format | Texte, Article |
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| Sujet | saxitoxin; sodium channel; paralytic shellfish poison; gymnodinium catenatum; hydroxybenzoate |
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| Résumé | The paralytic shellfish poison family has been recently extended by the discovery of several analogues possessing a hydoxybenzoate moiety instead of the carbamoyl group one finds in saxitoxin, the parent molecule of this toxin family. We have investigated the potency of these new analogues on a representative isoform of the pharmacological target of these toxins, the voltage gated sodium channel. These toxins were found to have KI's in the low nanomolar range, only slightly less potent than saxitoxin. The hydroxybenzoate group may increase the lipophilicity of these toxins and improve their ability to pass through epithelia and therefore its uptake and elimination in both intoxication victims and animals that bioaccumulate paralytic shellfish toxins. |
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| Date de publication | 2004-01 |
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| Conditions d’utilisation | - Copyright 2003 Elsevier Ltd. All rights reserved.
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | 1372 |
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| Numéro NPARC | 3538514 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | fa42dff1-5176-402b-a1bf-ff9c12628fea |
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| Enregistrement créé | 2009-03-01 |
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| Enregistrement modifié | 2020-04-17 |
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