Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects

Par Conseil national de recherches du Canada

Téléchargement	Voir le manuscrit accepté : Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects (PDF, 578 Kio)
DOI	Trouver le DOI : https://doi.org/10.1016/j.atherosclerosis.2003.12.015
Auteur	Rechercher : Wang, Yanwen; Rechercher : Jones, Peter J. H.; Rechercher : Ausmanb, Lynne M.; Rechercher : Lichtenstein, Alice H.
Format	Texte, Article
Sujet	Soy protein; Animal protein; Isoflavones; Lipid profiles; Cholesterol biosynthesis; Triglyceride fatty acid biosynthesis
Résumé	To examine the effects of protein source and isoﬂavones on triglyceride (TG) fatty acid (TGFA) and cholesterol biosynthesis, subjects (>50 years, LDL cholesterol >130 mg/dl) underwent a four-phase randomized cross-over feeding trial. Diets contained either isolated soy protein or common sources of animal protein (25 g/1000 kcal), without or with isoﬂavones (49 mg/1000 kcal) and were each fed for 6 weeks. Blood samples from 20 hyperlipidemic subjects (6M, 14F, 62 ± 9 years, BMI 26 ± 3 kg/m², LDL cholesterol >160 mg/dl after feeding animal protein without isoﬂavones) were selected to measure TGFA fractional synthetic rate (TGFA-FSR) and free cholesterol fractional synthetic rate (FC-FSR) over 24 h as deuterium oxide uptake into TGFA and free cholesterol. Soy protein reduced TG by 12.4% (P < 0.0001), total cholesterol by 4.4% (P < 0.001), and LDL cholesterol by 5.7% (P = 0.003) compared to animal protein. The TGFA-FSR was reduced by13.3% (P = 0.018) and FC-FSR was increased by 7.6% (P = 0.017) after the soy protein relative to the animal protein. Isoﬂavones had no signiﬁcant effect on TG and TGFA-FSR. Isoﬂavones reduced total cholesterol levels by 3.1% (P = 0.009) but had no signiﬁcant effect on LDL, HDL cholesterol levels, or FC-FSR. These data demonstrate that dietary protein type modulates circulating TG and cholesterol levels in hypercholesterolemic individuals by distinct mechanisms.
Date de publication	2004-04
Condition d’accès	available unlimited public
Dans	Atherosclerosis 173, nº April 2 (avril 2004) : 269–275.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro du CNRC	NRCC 54695
Numéro NPARC	9145566
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	0e0166e1-f654-4056-bf73-c80bae4b0556
Enregistrement créé	2009-10-02
Enregistrement modifié	2020-04-17

Date de modification :: 2024-07-07