| Téléchargement | - Voir la version finale : Zika virus crosses an in vitro human blood brain barrier model (PDF, 1.4 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.1186/s12987-018-0100-y |
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| Auteur | Rechercher : Alimonti, Judie B.1; Rechercher : Ribecco-Lutkiewicz, Maria1; Rechercher : Sodja, Caroline1; Rechercher : Jezierski, Anna1; Rechercher : Stanimirovic, Danica B.1; Rechercher : Liu, Qing; Rechercher : Haqqani, Arsalan S.1; Rechercher : Conlan, Wayne1; Rechercher : Bani-Yaghoub, Mahmud |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Sujet | Zika virus; brain endothelial cells; blood–brain barrier model; iPSC; AXL; neural progenitors |
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| Résumé | Zika virus (ZIKV) is a flavivirus that is highly neurotropic causing congenital abnormalities and neurological damage to the central nervous systems (CNS). In this study, we used a human induced pluripotent stem cell (iPSC)-derived blood brain barrier (BBB) model to demonstrate that ZIKV can infect brain endothelial cells (i-BECs) without compromising the BBB barrier integrity or permeability. Although no disruption to the BBB was observed post-infection, ZIKV particles were released on the abluminal side of the BBB model and infected underlying iPSC-derived neural progenitor cells (i-NPs). AXL, a putative ZIKV cellular entry receptor, was also highly expressed in ZIKV-susceptible i-BEC and i-NPs. This iPSC-derived BBB model can help elucidate the mechanism by which ZIKV can infect BECs, cross the BBB and gain access to the CNS. |
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| Date de publication | 2018-05-15 |
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| Maison d’édition | BMC |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 23004144 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 4bc86a85-4326-4aed-8044-176c02d7047c |
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| Enregistrement créé | 2018-10-02 |
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| Enregistrement modifié | 2020-05-30 |
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