| Téléchargement | - Voir le manuscrit accepté : A solution- and solid-phase approach to tetrahydroquinoline-derived polycyclics having a 10-membered ring (PDF, 772 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1021/cc049941o |
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| Auteur | Rechercher : Khadem, Shahriar1; Rechercher : Joseph, Reni1; Rechercher : Rastegar, Majid1; Rechercher : Leek, Donald M.1; Rechercher : Oudatchin, Kostantin A.1; Rechercher : Arya, Prabhat1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
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| Format | Texte, Article |
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| ISSN | 1520-4766 |
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| Résumé | With the goal of library generation using a polycyclic derivative 5 having an enamide functional group, a simple and practical, enantioselective synthesis of tetrahydroquinoline derivative 2 was achieved. The phenolic hydroxyl group in compound 2 was utilized as an anchoring site for solid-phase synthesis. The ring closing metathesis approach yielded the desired polycyclic product 5 on solid phase in five steps (overall 40% yield). Compound 5 is a novel scaffold for the library generation of natural product-like polycyclics having a functionalized medium ring for obtaining a new class of small molecules to be utilized as chemical probes. |
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| Date de publication | 2004-07-23 |
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| Dans | |
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| Langue | anglais |
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| Identificateur | 18517171 |
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| Numéro NPARC | 12340957 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 622ffa77-1e35-49ad-ae93-9b845cc2d3fe |
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| Enregistrement créé | 2009-09-11 |
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| Enregistrement modifié | 2020-04-17 |
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