| Téléchargement | - Voir la version finale : Modulation of bacterial multicellularity via spatio-specific polysaccharide secretion (PDF, 4.7 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.1371/journal.pbio.3000728 |
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| Auteur | Rechercher : Islam, Salim T.Identifiant ORCID : https://orcid.org/0000-0001-6853-8446; Rechercher : Vergara Alvarez, IsraelIdentifiant ORCID : https://orcid.org/0000-0002-3070-5365; Rechercher : Saïdi, Fares; Rechercher : Guiseppi, Annick; Rechercher : Vinogradov, Evgeny1Identifiant ORCID : https://orcid.org/0000-0002-5364-1376; Rechercher : Sharma, GauravIdentifiant ORCID : https://orcid.org/0000-0002-2861-7446; Rechercher : Espinosa, LeonIdentifiant ORCID : https://orcid.org/0000-0002-1923-2069; Rechercher : Morrone, Castrese; Rechercher : Brasseur, Gael; Rechercher : Guillemot, Jean-François; Rechercher : Benarouche, Anaïs; Rechercher : Bridot, Jean-Luc; Rechercher : Ravicoularamin, Gokulakrishnan; Rechercher : Cagna, Alain; Rechercher : Gauthier, CharlesIdentifiant ORCID : https://orcid.org/0000-0002-2475-2050; Rechercher : Singer, MitchellIdentifiant ORCID : https://orcid.org/0000-0001-6356-0863; Rechercher : Fierobe, Henri-Pierre; Rechercher : Mignot, TâmIdentifiant ORCID : https://orcid.org/0000-0003-4338-9063; Rechercher : Mauriello, Emilia M. F.Identifiant ORCID : https://orcid.org/0000-0001-9770-6138 |
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| Éditeur | Rechercher : Bollenbach, Tobias |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Sujet | polysaccharides; exopolysaccharides; protein domains; polymers; statistical data; emulsions; monosaccharides; pathogen motility |
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| Résumé | The development of multicellularity is a key evolutionary transition allowing for differentiation of physiological functions across a cell population that confers survival benefits; among unicellular bacteria, this can lead to complex developmental behaviors and the formation of higher-order community structures. Herein, we demonstrate that in the social δ-proteobacterium Myxococcus xanthus, the secretion of a novel biosurfactant polysaccharide (BPS) is spatially modulated within communities, mediating swarm migration as well as the formation of multicellular swarm biofilms and fruiting bodies. BPS is a type IV pilus (T4P)-inhibited acidic polymer built of randomly acetylated β-linked tetrasaccharide repeats. Both BPS and exopolysaccharide (EPS) are produced by dedicated Wzx/Wzy-dependent polysaccharide-assembly pathways distinct from that responsible for spore-coat assembly. While EPS is preferentially produced at the lower-density swarm periphery, BPS production is favored in the higher-density swarm interior; this is consistent with the former being known to stimulate T4P retraction needed for community expansion and a function for the latter in promoting initial cell dispersal. Together, these data reveal the central role of secreted polysaccharides in the intricate behaviors coordinating bacterial multicellularity. |
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| Date de publication | 2020-06-09 |
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| Maison d’édition | Public Library of Science |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 75609f43-bc94-4885-b235-10ea415af969 |
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| Enregistrement créé | 2021-05-12 |
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| Enregistrement modifié | 2021-05-17 |
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