| DOI | Trouver le DOI : https://doi.org/10.1006/bbrc.1997.7908 |
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| Auteur | Rechercher : Gruwel, Marco L.H.1; Rechercher : Čulić, Ognjen; Rechercher : Muhs, Andreas; Rechercher : Williams, John P.; Rechercher : Schrader, Jürgen |
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| Affiliation | - Conseil national de recherches du Canada
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| Format | Texte, Article |
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| Résumé | Using anin vitrocell system and Cs⁺NMR techniques we were able to show that porcine aortic endothelial cells (PAEC) reduce their Na⁺-K⁺-ATPase activity upon an increase in intracellular cAMP. Reduction in the pump rate was due to phosphorylation of the α-subunit of the ATPase as shown by immunoprecipitation. Apart from a pump inhibiton using 8-Br-cAMP and IBMX, we were also able to show that changes in the Na⁺-K⁺-ATPase activity could be mediated by the adenosine-A₂and prostaglandin receptor agonists 5′-N-Ethylcarboxamidoadenosine and Iloprost, respectively. Parallel to a decrease in pump activity we also observed a decrease in intracellular Cs⁺, indicating opening of K⁺channels. |
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| Date de publication | 1998-01 |
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| Maison d’édition | Elsevier |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | S0006291X97979080 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | b3783b77-f367-49d6-be99-7a27fd5be945 |
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| Enregistrement créé | 2023-11-01 |
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| Enregistrement modifié | 2023-11-01 |
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