| Téléchargement | - Voir la version finale : Terrosamycins A and B, bioactive polyether ionophores from Streptomyces sp. RKND004 from Prince Edward Island sediment (PDF, 940 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.3390/md17060347 |
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| Auteur | Rechercher : Sproule, Amanda; Rechercher : Correa, Hebelin; Rechercher : Decken, Andreas; Rechercher : Haltli, Bradley; Rechercher : Berrué, Fabrice1; Rechercher : Overy, David P.; Rechercher : Kerr, Russell G. |
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| Affiliation | - Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
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| Format | Texte, Article |
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| Sujet | Streptomyces; X-ray diffraction; antibiotic; marine sediment; metabolomics; polycyclic polyether |
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| Résumé | Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of these compounds. The structure of 1 was determined from analysis of NMR, HRMS, and X-ray diffraction data. NMR experiments performed on 2 revealed the presence of two methoxy groups replacing two hydroxy groups in 1. Like other polyether ionophores, 1 and 2 exhibited excellent antibiotic activity against Gram-positive pathogens. Interestingly, the terrosamycins also exhibited activity against two breast cancer cell lines. |
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| Date de publication | 2019-06-11 |
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| Maison d’édition | MDPI |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | NRC-ACRD-PDB006 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | cd05e796-70c0-4077-a28b-b1faca811c14 |
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| Enregistrement créé | 2019-07-09 |
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| Enregistrement modifié | 2020-05-30 |
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