| Téléchargement | - Voir la version finale : Is clathrin involved in internalization of the small molecule berberine by primary mouse mast cells? (PDF, 953 Kio)
|
|---|
| DOI | Trouver le DOI : https://doi.org/10.26502/ami.93650082 |
|---|
| Auteur | Rechercher : Alam, Syed Benazir1; Rechercher : Kulka, Marianna1 |
|---|
| Affiliation | - Conseil national de recherches du Canada. Nanotechnologie
|
|---|
| Format | Texte, Article |
|---|
| Sujet | endocytosis; mast cells; interleukin-3; berberine; cell cycle; clathrin |
|---|
| Résumé | The internalization and endocytosis of small molecules is a process that relies on either passive diffusion across the cell membrane or active transport through complex endocytic pathways such as pinocytosis. Using the fluorescent benzylisoquinoline compound berberine (BBR) as a tool, we analyzed the internalization of this small molecule by differentiated mouse bone marrow-derived mast cells. Our recent data showed that internalization of this compound was energy-and time-dependent and was increased when cells were treated with the differentiation cytokine, interleukin-3 (IL-3). In this commentary, we examine some of the possible mechanisms of internalization and provide further data to show that this process is partially dependent on clathrin-mediated endocytosis. Our hypothesis is that BBR internalization may utilize several pathways of internalization depending upon cell activation and proliferation. |
|---|
| Date de publication | 2022-04-26 |
|---|
| Maison d’édition | Fortune Journals |
|---|
| Licence | |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Numéro du CNRC | NRC-NANO-225 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | d8374487-9d84-45ca-b5f2-ea4f44bba99a |
|---|
| Enregistrement créé | 2023-01-03 |
|---|
| Enregistrement modifié | 2023-01-03 |
|---|
